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Institute for Advanced Academic Research / Faculty of Medicine, Chiba University
Associate ProfessorMy research aims to elucidate the mechanisms underlying autoimmunity and allergy.
In particular:
1) Uncovering the diverse role of IL-21, a pleiotropic cytokine, across various immune reactions and deciphering the regulatory mechanisms behind IL-21 production.
2) Elucidating the functions of Sox family molecules, identified during the process mentioned in 1), in the differentiation of helper T cells and regulatory T cells.
3) Investigating the mechanism of action of methotrexate, a key therapeutic agent for rheumatoid arthritis.
Recent Topics of Interests:
The development and maintenance of IL-17-producing γδT cells (γδT17 cells) and their role in autoimmunity and tumor immunity
Motto in Research or in Life: The truth is in the details / Let it be
Hobby / Holiday: Tennis, Jogging, Housework, Playing with my Cat
Faculty of Medicine, Chiba University / Health and Disease Omics Center
Professor / DirectorCells accumulate abnormalities in their genomic and epigenomic information, which can lead to diseases like cancer. The epigenome, which involves modifications to the genome, changes due to environmental factors and stress such as aging, infection, and inflammation in somewhat defined manners, resulting in cell fate alteration. Exploring and harnessing the accumulated epigenomic aberrations is a crucial step in elucidating cancer and developing novel cancer treatments.
Recent Topics of Interests:
Cancer risk diagnosis, Integrated omics analysis
Motto in Research or in Life: Insatiable inquiry and challenge
Institute for Advanced Academic Research / Faculty of Medicine / Research Institute of Disaster Medicine, Chiba University
ProfessorThe genome is the blueprint of life. The “which part” of the genome is read differs in each cell, and the addition or deletion of the methyl group CH3- (just four atoms) plays an important role in reading the genome. This mechanism is known as epigenetic modification, and the development of next-generation sequencing technology has greatly contributed to this research field. Epigenetic modifications by methyl groups can be classified into two types: (1) methylation of histones and (2) methylation of DNA cytosines. Our previous research showed that histone methylations regulated by the Polycomb and Trithorax group proteins are essential for immune responses, particularly those mediated by T cells. In addition, our recent international collaborative study revealed that TET enzymes, which convert methyl-cytosine into hydroxymethyl-cytosine, inhibit inflammation and tumor development in mice and humans. Currently, our study focuses on the relationship between age-related epigenetic abnormalities and immune diseases, which has received much attention in recent years. The final goal of my research is to solve the mysteries of life and ultimately control diseases by concentrating our wisdom on physics, chemistry, and mathematics.
Recent Topics of Interests:
Cancer immunotherapy by epigenetic manipulation, Immuno-aging caused by epigenetic abnormalities, Integrative single-cell multi-omics analyses
Motto in Research or in Life:
The motto in research: Let’s enjoy science!
The motto in life: “If you put your mind to it, you could accomplish anything.” This quote is cited from Back to the Future, Universal Pictures, 1985.
Hobby / Holiday:
Reading books, Watching baseball games, Insect hunting
Faculty of Medicine, Chiba University / Research Center for Child Mental Development
Professor / DirectorI am researching cognitive-behavioral therapy, which is a psychotherapy that aims to help people, including Adolescents and Young Adults (AYA generation), manage their emotional problems by changing negative thinking habits and behavioral patterns for better mental health.
Recent Topics of Interest: "Memory Rescripting"
Motto in Research or in Life: There is no pleasure without pain. Fall down seven times, stand up eight.
Hobby / Holiday: Watching movies
Faculty of Medicine, Chiba University
ProfessorMy research interest in analyzing lipid peroxides and drug poisons was sparked by my involvement in detecting sarin metabolites from the victims of the Tokyo subway sarin attack in 1995. Furthermore, I have been at the forefront of introducing postmortem imaging diagnosis with CT in forensic medicine in Japan. Additionally, I have conducted extensive research on death investigation systems and postmortem imaging examinations.
Recent Topics of Interests:
How to prevent similar accidents, suicides, abuse, and other unnatural deaths by utilizing the information obtained from death investigations (such as child death review).
How to establish a system and a mechanism for accurately determining the cause of death by appropriately utilizing various examinations such as postmortem imaging, autopsy, and drug testing.
Motto in Research or in Life:
Do right, have fun, and make friends.
The answer is not limited to 0 or 1, but there can be multiple possibilities including 1/2 and √2.
Stay hungry, stay foolish.
Justice for all.
Hobby / Holiday: Walking, Sleeping, and Watching baseball
Institute for Advanced Academic Research / Faculty of Medicine, Chiba University
Associate ProfessorI conduct research aimed at discovering diagnostic markers and therapeutic targets through integrating clinical information and omics data, such as comprehensive gene expression (transcriptome) and protein expression (proteome) using clinical specimens. Additionally, I work on elucidating the regulatory mechanisms of gene expression during the differentiation process by using cell models.
Recent Topics of Interests: Stratification and prognostication of disease based on omics data
Motto in Research or in Life: Spirit of a rag (a willingness to contribute to society even at the cost of personal sacrifice)
Hobby / Holiday: I feel happiest when I spend time with my family.
Faculty of Medicine / Research Institute of Disaster Medicine, Chiba University
ProfessorI graduated from Chiba University School of Medicine in 1984 and subsequently joined the Department of Neuropsychiatry at Chiba University. In 1986, I embarked on a research position at the National Center for Psychiatry and Neurology, followed by a visiting researcher role at the National Institutes of Health (NIH) in the United States in 1988. Upon my return to Japan, I held several key positions, including Director of the Drug Dependence Laboratory at the Institute of Mental Health, National Center for Neurology and Psychiatry, and Associate Professor of Neuropsychiatry at Hamamatsu University School of Medicine. Eventually, in 2000, I joined Chiba University.
My areas of expertise include psychopharmacology, cognitive-behavioral therapy, establishing community mental health care systems, disaster and emergency psychiatric medicine, sports psychiatry, and forensic psychiatry. In recent years, my research has been primarily focused on advancing our understanding of the pathology of schizophrenia, with a particular emphasis on treatment-resistant schizophrenia. I am dedicated to developing effective treatment methods for this condition.''
Faculty of Medicine, Chiba University
LecturerI am currently engaged in basic cancer research, with a particular focus on T cell-mediated anti-tumor immune responses in tumor-draining lymph nodes. I truly hope our research will contribute to developing innovative cancer immunotherapies.
Recent Topics of Interests:
・Fate determination of tumor-specific CD8T cells
・Molecular function of an activation marker CD69
Motto in Research or in Life: If Winter comes, can Spring be far behind?
Hobby / Holiday: Spending time with family, Exercising
Faculty of Medicine, Chiba University
Assistant ProfessorI specialize in the diagnosis and treatment of ankle and foot-related conditions, as well as conducting research in this field.
During my Ph.D. studies, I conducted research on the use of platelet-rich plasma (PRP), a hot topic in sports orthopedics and regenerative medicine, to promote tendon repair following Achilles tendon rupture.
Recent Topics of Interest: Utilization of ultrasound (echo) in foot-related issues.
Motto in Research or in Life: Let’s have fun together.
Hobby / Holiday: Tennis, Family Outing
Faculty of Medicine, Chiba University
Professor and DeanI am conducting fundamental medical research on the regulation of sugar and energy metabolism. My primary research interests lie in investigating inter-organ networks and intracellular signal pathways. Specifically, I am exploring innovative treatments for conditions such as diabetes, obesity, and non-alcoholic fatty liver disease.
Additionally, I actively contribute to promoting research in the field of disaster medicine, with the ultimate goal of fostering a resilient society that can effectively protect people's health during and after emergencies and disasters.
Motto in Research or in Life:
Necessity is the mother of invention. Where there's a will, there's a way. Nothing ventured, nothing gained.
