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Institute for Advanced Academic Research / Faculty of Medicine, Chiba University
Associate ProfessorMy research aims to elucidate the mechanisms underlying autoimmunity and allergy.
In particular:
1) Uncovering the diverse role of IL-21, a pleiotropic cytokine, across various immune reactions and deciphering the regulatory mechanisms behind IL-21 production.
2) Elucidating the functions of Sox family molecules, identified during the process mentioned in 1), in the differentiation of helper T cells and regulatory T cells.
3) Investigating the mechanism of action of methotrexate, a key therapeutic agent for rheumatoid arthritis.
Recent Topics of Interests:
The development and maintenance of IL-17-producing γδT cells (γδT17 cells) and their role in autoimmunity and tumor immunity
Motto in Research or in Life: The truth is in the details / Let it be
Hobby / Holiday: Tennis, Jogging, Housework, Playing with my Cat
Institute for Advanced Academic Research / Faculty of Medicine / Research Institute of Disaster Medicine, Chiba University
ProfessorThe genome is the blueprint of life. The “which part” of the genome is read differs in each cell, and the addition or deletion of the methyl group CH3- (just four atoms) plays an important role in reading the genome. This mechanism is known as epigenetic modification, and the development of next-generation sequencing technology has greatly contributed to this research field. Epigenetic modifications by methyl groups can be classified into two types: (1) methylation of histones and (2) methylation of DNA cytosines. Our previous research showed that histone methylations regulated by the Polycomb and Trithorax group proteins are essential for immune responses, particularly those mediated by T cells. In addition, our recent international collaborative study revealed that TET enzymes, which convert methyl-cytosine into hydroxymethyl-cytosine, inhibit inflammation and tumor development in mice and humans. Currently, our study focuses on the relationship between age-related epigenetic abnormalities and immune diseases, which has received much attention in recent years. The final goal of my research is to solve the mysteries of life and ultimately control diseases by concentrating our wisdom on physics, chemistry, and mathematics.
Recent Topics of Interests:
Cancer immunotherapy by epigenetic manipulation, Immuno-aging caused by epigenetic abnormalities, Integrative single-cell multi-omics analyses
Motto in Research or in Life:
The motto in research: Let’s enjoy science!
The motto in life: “If you put your mind to it, you could accomplish anything.” This quote is cited from Back to the Future, Universal Pictures, 1985.
Hobby / Holiday:
Reading books, Watching baseball games, Insect hunting
Institute for Advanced Academic Research / International Center for Hadron Astrophysics, Chiba University
ProfessorHigh-energy phenomena, which occur in the universe beyond human creation, remain mysterious in terms of their mechanisms. Through various observations, my aim is to elucidate the origins and locations of these extraordinary events. Specifically, my research focuses on studying high-energy phenomena in space by observing neutrinos, which are elementary particles that traverse through space.
Recent Topics of Interests:
Development of Next Generation Neutrino Telescopes, Development of New Detection Techniques with Neutrino Telescopes
Motto in Research or in Life: Even if others oppose you, if you follow your curiosity, you won't regret it.
Hobby / Holiday: Reading books and listening to music
Institute for Advanced Academic Research / Faculty of Science, Chiba University
Assistant ProfessorAnimals often appear to adhere to certain behavioral rules, yet they exhibit distinct behavioral patterns among individuals, called personalities. Such diversity among individuals can be beneficial for a group. I am investigating the molecular and evolutionary mechanisms behind the emergence of behavioral diversity, possibly providing insights into our societies.
Recent Topics of Interests: Genetics behind emergent properties of collective behavior.
Motto in Research or in Life: You are what you do.
Hobby / Holiday: Running, Badminton
Institute for Advanced Academic Research, Chiba University
Professor / Special Advisor to the PresidentI specialize in the fields of international politics and comparative politics. My research initially focused on democratization in Southeast Asia and has since shifted towards examining the end of the Cold War and post-Cold War conflicts, starting from the 1990s.
Recent Topics of Interest:
Russian invasion of Ukraine
Disintegration of international politics
Transition from globalism to de-globalism
Global South in International Politics
Motto in Research or in Life:
The sweat shed for peace reduces the blood shed in war
Hobby / Holiday:
Watching movies
Institute for Advanced Academic Research / Faculty of Horticulture, Chiba University
Associate ProfessorI am collaborating with the Institute of Fruit Tree and Tea Science, National Agriculture and Food Research Organization, to conduct research aimed at developing efficient breeding methods for fruit trees using genomic information. Specifically, I am working on the development of a method called genomic selection (GS), which predicts the characteristics of future fruits, such as pericarp color and fruit weight, at the seedling stage, enabling early selection.
Recent Topics of Interest:
I am interested in researching how to extract essential information from big data, such as genomes and images, and how to utilize this information for the breeding of fruit trees.
Motto in Research or in Life: Practice makes perfect. Constant dripping wears away a stone.
Hobby / Holiday: I enjoy spending time with children, homemaking, and swimming.
Institute for Advanced Academic Research / Faculty of Medicine, Chiba University
Associate ProfessorI conduct research aimed at discovering diagnostic markers and therapeutic targets through integrating clinical information and omics data, such as comprehensive gene expression (transcriptome) and protein expression (proteome) using clinical specimens. Additionally, I work on elucidating the regulatory mechanisms of gene expression during the differentiation process by using cell models.
Recent Topics of Interests: Stratification and prognostication of disease based on omics data
Motto in Research or in Life: Spirit of a rag (a willingness to contribute to society even at the cost of personal sacrifice)
Hobby / Holiday: I feel happiest when I spend time with my family.
Institute for Advanced Academic Research / Faculty of Engineering, Chiba University
ProfessorI am conducting research aimed at creating ‘meaningful structures’ in the mesoscale, which connects the nanoscale and microscale, through the assembly of molecules.
Given that crucial functions within living organisms heavily rely on mesoscale structures, my goal is to artificially fabricate such structures to generate novel functionalities.
Recent Topics of Interests:
Development of a method to assemble nanostructures into more complex hierarchical structures
Motto in Research or in Life:
Not being afraid to fail
Respecting others
Hobby / Holiday: Searching for addicting music, Going out to places my kids love
Institute for Advanced Academic Research / Center for Environmental Remote Sensing, Chiba University
Professor My laboratory is pursuing environmental prediction research, with a focus on various Earth environmental phenomena such as meteorological and hydrological events. I strive to advance the boundaries of this field by integrating Earth observation satellites and employing diverse prediction methods. Specifically, I am committed to enhancing and refining weather forecasts for extended periods of several weeks, and gaining a comprehensive understanding of the long-term impact of climate change on the water resource environment over a century.
To achieve my prediction refinement goals, I employ numerical simulations powered by state-of-the-art supercomputers and harness the potential of machine learning techniques. I will facilitate the fusion of forecast and observation data through statistical mathematics, including data assimilation. My ambition is to pioneer a groundbreaking environmental prediction science by conducting interdisciplinary research that spans earth science, computational science, and statistical mathematics.
Recent Topics of Interest:
Seasonal forecasting, Weather control, Social consensus building, and Optimization of observation location
Motto in Research or in Life:
The good is the enemy of the best.
Before you can inspire with emotion, you must be swamped with it yourself. Before you can move their tears, your own must flow. To convince them, you must yourself, believe.
Hobby / Holiday:
Reading books, Observing behaviors and activities of my son
Institute for Advanced Academic Research / Faculty of Medicine, Chiba University
Associate ProfessorThe “intestinal mucosa” serves not only as a site for digestion and absorption, but also plays a crucial role in biological regulation, including the immune system. Through research on intestinal mucosal immunity, we are making efforts to establish treatments for diseases such as fibrotic and allergic diseases (e.g., inflammatory bowel disease and food allergy), which can result in multi-organ failure. Furthermore, in recent years, intestinal bacteria capable of crossing the intestinal barrier and infecting and translocating extra-intestinal organs have been regarded as the potential “causes of various diseases.” Therefore, we are conducting research aimed to identify and control pathogenic commensal bacteria. Our ongoing immunological research is progressing diligently and steadily.
Recent Topics of Interest: Organ axis, Pathogenic commensal bacteria, Peripheral immune education, Inflammatory bowel disease
Motto in Research or in Life: When the going gets tough, the tough get going.
Fixed ideas are evil; prejudices are sin.
Hobby / Holiday: Martial arts, Movies, Photography
