Methylated Cyclodextrin Effectively Prevents the Crystallization of Supersaturated Drugs

2023.05.15

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Supersaturating poorly soluble drugs is a promising strategy to improve their bioavailability and oral adsorption. However, stabilizers are often necessary to maintain drug supersaturation and prevent crystallization. Recently, researchers explored the stabilizing effects of various cyclodextrin derivatives on the supersaturation of two model drugs, chlorthalidone and carvedilol, finding that methylated derivatives with higher hydrophobicity maintained drug supersaturation for longer periods. This study could help develop effective supersaturated drug formulations and facilitate their clinical use.

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